Publications

PI5P4K inhibitors: promising opportunities and challenges.

Takeuchi K, Nagase L, Kageyama S, Kanoh H, Oshima M, Ogawa-Iio A, Ikeda Y, Fujii Y, Kondo S, Osaka N, Masuda T, Ishihara T, Nakamura Y, Hirota Y, Sasaki T, Senda T, Sasaki AT.

FEBS J. 2025 Jan 19. doi: 10.1111/febs.17393. Online ahead of print.
PMID: 39828902

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.

Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT.

Biochem Biophys Res Commun. 2024 Jul 23;718:149981

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.

Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT.

Biochem Biophys Res Commun. 2023 Oct 30;679:116-121. doi: 10.1016/j.bbrc.2023.08.050. Epub 2023 Aug 26.
PMID: 37683456

Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ.

akeuchi K, Senda M, Ikeda Y, Okuwaki K, Fukuzawa K, Nakagawa S, Sasaki M, Sasaki AT, Senda T.

FEBS J. 2023 Sep;290(18):4419-4428. doi: 10.1111/febs.16763. Epub 2023 Mar 10.
PMID: 36856076

The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.

K. Takeuchi, Y. Ikeda, M. Senda, A. Harada, F. Okuwaki, K. Fukuzawa, S. Nakagawa, H.Y. Yu, L. Nagase, M. Imai, M. Sasaki, Y-H. Lo, D. Ito, N. Osaka, Y. Fujii, A.T. Sasaki, T. Senda.

Structure. 2022 Jun 2;30(6):886-899.e4. doi: 10.1016/j.str.2022.04.004.

PMID: 35504278

Divergent Mechanisms Activating RAS and Small GTPases Through Post-Translational Modification.

N. Osaka, Y. Hirota, D. Ito, Y. Ikeda, R. Kamata, Y. Fujii, V. R. Chirasani, S. L. Campbell, K. Takeuchi, T. Senda, & A. T. Sasaki.

Front. Mol. Biosci. 2021, 8 (July), 1–12. doi: 10.3389/fmolb.2021.707439.

PMID: 34307463.

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

R. Naffouje, P. Grover, H. Yu, A. Sendilnathan, K. Wolfe, N. Majd, E. P. Smith, K. Takeuchi, T. Senda, S. Kofuji, & A. T. Sasaki.

Cancers (Basel). 2019, 11 (9), 1–30. doi: 10.3390/cancers11091346.

PMID: 31514446.

IMP Dehydrogenase-2 Drives Aberrant Nucleolar Activity and Promotes Tumorigenesis in Glioblastoma.

S. Kofuji, A. Hirayama, A. O. Eberhardt, R. Kawaguchi, Y. Sugiura, O. Sampetrean, Y. Ikeda, M. Warren, N. Sakamoto, S. Kitahara, H. Yoshino, D. Yamashita, K. Sumita, K. Wolfe, L. Lange, S. Ikeda, H. Shimada, N. Minami, A. Malhotra, S. Morioka, Y. Ban, M. Asano, V. L. Flanary, A. Ramkissoon, L. M. L. Chow, J. Kiyokawa, T. Mashimo, G. Lucey, S. Mareninov, T. Ozawa, N. Onishi, K. Okumura, J. Terakawa, T. Daikoku, T. Wise-Draper, N. Majd, K. Kofuji, M. Sasaki, M. Mori, Y. Kanemura, E. P. Smith, D. Anastasiou, H. Wakimoto, E. C. Holland, W. H. Yong, C. Horbinski, I. Nakano, R. J. DeBerardinis, R. M. Bachoo, P. S. Mischel, W. Yasui, M. Suematsu, H. Saya, T. Soga, I. Grummt, H. Bierhoff, & A. T. Sasaki.

Nat. Cell Biol. 2019, 21 (8), 1003–1014. doi: 10.1038/s41556-019-0363-9.

PMID: 31371825.

Structural Reverse Genetics Study of the PI5P4Kβ–Nucleotide Complexes Reveals the Presence of the GTP Bioenergetic System in Mammalian Cells.

K. Takeuchi, M. Senda, Y. H. Lo, S. Kofuji, Y. Ikeda, A. T. Sasaki, & T. Senda.

FEBS J. 2016, 283 (5), 3556–3562. doi: 10.1111/febs.13739.

PMID: 27090388.

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

K. Sumita, Y. H. Lo, K. Takeuchi, M. Senda, S. Kofuji, Y. Ikeda, J. Terakawa, M. Sasaki, H. Yoshino, N. Majd, Y. Zheng, E. R. Kahoud, T. Yokota, B. M. Emerling, J. M. Asara, T. Ishida, J. W. Locasale, T. Daikoku, D. Anastasiou, T. Senda, & A. T. Sasaki.

Mol. Cell 2016, 61 (2), 187–198. doi: 10.1016/j.molcel.2015.12.011.

PMID: 26774281.

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