Publications

The GTP responsiveness of PI5P4Kβ evolved from a compromised trade-off between activity and specificity.

K. Takeuchi, Y. Ikeda, M. Senda, A. Harada, F. Okuwaki, K. Fukuzawa, S. Nakagawa, H.Y. Yu, L. Nagase, M. Imai, M. Sasaki, Y-H. Lo, D. Ito, N. Osaka, Y. Fujii, A.T. Sasaki, T. Senda.

Structure

2022

10.1016/j.str.2022.04.004.

Doi:

Jun 2;30(6)

886-899.e4

PMID:

35504278

Divergent Mechanisms Activating RAS and Small GTPases Through Post-Translational Modification.

N. Osaka, Y. Hirota, D. Ito, Y. Ikeda, R. Kamata, Y. Fujii, V. R. Chirasani, S. L. Campbell, K. Takeuchi, T. Senda, & A. T. Sasaki.

Mol. Biosci.

2021

10.3389/fmolb.2021.707439

Doi:

8 (July)

1–12

PMID:

34307463

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story.

R. Naffouje, P. Grover, H. Yu, A. Sendilnathan, K. Wolfe, N. Majd, E. P. Smith, K. Takeuchi, T. Senda, S. Kofuji, & A. T. Sasaki.

Cancers (Basel).

2019

10.3390/cancers11091346

Doi:

11 (9)

1–30

PMID:

31514446

IMP Dehydrogenase-2 Drives Aberrant Nucleolar Activity and Promotes Tumorigenesis in Glioblastoma.

S. Kofuji, A. Hirayama, A. O. Eberhardt, R. Kawaguchi, Y. Sugiura, O. Sampetrean, Y. Ikeda, M. Warren, N. Sakamoto, S. Kitahara, H. Yoshino, D. Yamashita, K. Sumita, K. Wolfe, L. Lange, S. Ikeda, H. Shimada, N. Minami, A. Malhotra, S. Morioka, Y. Ban, M. Asano, V. L. Flanary, A. Ramkissoon, L. M. L. Chow, J. Kiyokawa, T. Mashimo, G. Lucey, S. Mareninov, T. Ozawa, N. Onishi, K. Okumura, J. Terakawa, T. Daikoku, T. Wise-Draper, N. Majd, K. Kofuji, M. Sasaki, M. Mori, Y. Kanemura, E. P. Smith, D. Anastasiou, H. Wakimoto, E. C. Holland, W. H. Yong, C. Horbinski, I. Nakano, R. J. DeBerardinis, R. M. Bachoo, P. S. Mischel, W. Yasui, M. Suematsu, H. Saya, T. Soga, I. Grummt, H. Bierhoff, & A. T. Sasaki.

Nat. Cell Biol.

2019

10.1038/s41556-019-0363-9

Doi:

21 (8)

1003–1014

PMID:

31371825

Structural Reverse Genetics Study of the PI5P4Kβ–Nucleotide Complexes Reveals the Presence of the GTP Bioenergetic System in Mammalian Cells.

K. Takeuchi, M. Senda, Y. H. Lo, S. Kofuji, Y. Ikeda, A. T. Sasaki, & T. Senda.

FEBS J.

2016

10.1111/febs.13739

Doi:

283 (5)

3556–3562

PMID:

27090388

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.

K. Sumita, Y. H. Lo, K. Takeuchi, M. Senda, S. Kofuji, Y. Ikeda, J. Terakawa, M. Sasaki, H. Yoshino, N. Majd, Y. Zheng, E. R. Kahoud, T. Yokota, B. M. Emerling, J. M. Asara, T. Ishida, J. W. Locasale, T. Daikoku, D. Anastasiou, T. Senda, & A. T. Sasaki.

Mol. Cell.

2016

10.1016/j.molcel.2015.12.011.

Doi:

61 (2)

187–198

PMID:

26774281